Effect of Zinc on Serum Testosterone Level in Albino Rats

  • Mohammad Sair Assistant Professor, Department of Pharmacology and therapeutics, Islam Medical and Dental College, Pasrur road Sialkot
  • Mohammad Nauman Shad Associate Professor, Sahara Medical College, Narowal
  • Sana Imran Assistant Professor, Jinnah Sindh Medical University, Karachi
  • Moosa Khan Professor, Shaheed Zulfiqar Ali Bhutto Medical University, Islamabad
Keywords: fertility, serum, testosterone level, Indomethacin


Objective: To study the effect of zinc on serum testosterone levels in Albino rats.
Material and Methods: This study was conducted in the Department of Pharmacology and Therapeutics BMSI JPMC Karachi. In this study 60 albino rats were divided into four groups, 15 rats in each group. Group one was control group (normal diet was given to this group), group two was given indomethacin, group three was given zinc and group four was given combination of Zinc and indomethacin. All the drugs were given for 12 weeks. Serum testosterone level was checked at the end of study and finally data was analyzed statistically using SPSS version 18.
Results: In group 2, serum testosterone level (3.12±0.63) was low as compared with control (6.26±0.15). In group 3, mean testosterone was high (6.97±0.63) when it was compared with control (6.26±0.15). In group 4, mean testosterone was low (5.15±0.73) but not significant when compared with control (6.26±0.15).
Conclusion: Zinc has a protective role on testes and it increases testosterone and fertility. 

Original Articles