Preoperative Thrombophilia Profile in Living Liver Donors from Pakistan

Abstract

Objective: To determine the frequency of thrombophilia disorders among healthy Pakistani liver transplant donors through extended thrombophilia screening.

Methodology: Descriptive, cross- sectional study was conducted at department of hematology, Shifa International Hospital, Islamabad from January 2020 to July 2024. A total of 362 living liver donors were selected who met the inclusion criteria. Blood samples were collected in sodium citrate tubes for extended thrombophilia screening which includes quantitative measurements of Protein C, Protein S, Antithrombin and Lupus anticoagulant. Data was analyzed using the Statistical Package for Social Sciences version 25.0.

Results: The frequency of thrombophilia markers was as follow: Protein C deficiency 5.2%, AT deficiency 13.8%, Protein S deficiency 18.8%. Lupus anticoagulant was positive in 1.4% of donors

Conclusion: Pre-operative thrombophilia profile in living liver donors from Pakistan revealed significant prevalence of hereditary thrombophilia markers within the donor population. Extended thrombophilia screening protocol for LLDs is essential for identifying at risk individuals guiding appropriate perioperative thromboprophylaxis and ultimately improving the safety of both donors and recipients undergoing LLDT

Key words: Living liver donors, Living Liver Donor Transplantation, Protein C, Protein S, Antithrombin